Leading the way in biomaterials!

by YPU Admin on January 18, 2018. Tags: Biomaterials, cells, nanoscience, PhD, and Research

Introduction

Hi! My name is Zara Smith and I’m a 2nd year PhD student at the University of Manchester. I’m funded by EPSRC (Engineering and Physical Sciences Research Council) and am currently based on the North Campus of the university. I am part of the Biomaterials research group headed by Prof. Julie Gough.

I finished high school in 2011, with A levels in Biology, Chemistry and English Literature.  Though my decision to study Biology was a quick one and rather rushed, I REALLY enjoyed studying for my undergraduate degree at the University of Hull, and loved it enough to continue onto a Master’s degree in Nanotechnology and Regenerative Medicine at UCL. I took a year out following this and worked as a Trainee Assistant Analytical Chemist for TATA Steel in their environmental monitoring department, before deciding on my PhD project. My work at Manchester focuses on repairing tissues in the body that naturally would not heal by themselves. I work specifically with the Anterior Cruciate Ligament (ACL), a major knee ligament, which accounts for the majority of sports injuries and has a high rate of reintervention post-surgery.

So far my PhD has been great! I’ve travelled to a European conference in Switzerland to present my work and been to another here in Manchester, where I have met academics from all over the world. Hopefully there will be many more opportunities to share my research with the academic community!

In Depth...

I first became interested in the field of Biomaterials when I was doing my undergraduate degree, specifically the tiny biological interactions that happen at a surface and how we can use those interactions to guide a desired biological response. I have always been interested in creating biomedical devices and helping to create something which would improve the life of an individual and the medical field in that area, seemed almost like a calling! After graduating from my Biology degree, I immediately began my Masters. I completed a research project on the nano-delivery of growth factors to a model central nervous system, which only served to fuel my interest in the bio-responses of cells to materials on the micro and nano scale. 

After the completion of my Master’s degree, though knowing I wanted to do a PhD, I decided it was time to take a year out, gather some industrial experience and take the time to find a project that aligned with my interests. During this year, I was selected for an assistant position at TATA Steel where I performed both regular sampling analysis and novel research in analytical chemistry. I chose the ACL project at Manchester as it sounded fascinating and combined all the areas I find interesting; fast forward a year and I still absolutely love it! The project itself focuses on producing materials that will encourage cells taken from the ACL to produce a protein scaffold that matches as closely as possible the protein scaffold present in the native ACL. This means that the cells will start laying down the protein building blocks that are integral to building a native ACL, replacing the one that has already been irreparably damaged. We are aiming to achieve this through manipulating the cells at the surface of the materials with both physical cues and proteins.

(A picture of ACL cells from a light microscope!)

For the most part, my days usually consist of lab work, planning experiments, data analysis and reading and writing.

Due to the nature of the field, our group is highly interdisciplinary. We have members from all kinds of disciplinary backgrounds spanning biological sciences, chemistry and all types of engineering. This in itself makes for a very interesting working environment where minds from very different backgrounds can come together and work to build materials/technologies.

 

Going Further...

If you are interested in perusing Materials sciences, the University of Manchester School of Materials webpage is here > http://www.materials.manchester.ac.uk/

Interested in the Biomaterials work in my group? Find out more here > http://personalpages.manchester.ac.uk/staff/j.gough/ and here > http://www.materials.manchester.ac.uk/our-research/research-groupings/biomaterials/

We also have a school blog which details life as a materials student and interviews a range of students and lecturers > http://www.mub.eps.manchester.ac.uk/uommaterialsblog/  

If you are interested in the societies associated with biomaterials research, take a look here > https://www.uksb.org.uk/


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