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Cancer Research at the Christie Hospital

Introduction

Hi, my name is Shreya, a Master's student at the University of Manchester. My Master’s is in cancer research, an extremely topical and fast paced field. After completing three years of medicine, I decided to take a year out, known as 'intercalating', to explore research.

The knowledge of how innovative and pioneering the current projects are, coupled with the fact that I had a previous interest in the clinical side of cancer, solidified that this was the field for me. After this year I’ll return to finishing my medical degree, now with the perspective of working as a researcher. The invaluable skills I’ve learnt and will continue to develop this year should only help me become a better doctor in the future.

In Depth...

My research is focused on colorectal cancer, one of the most common cancers in the UK. The project I’m doing specifically involves patients that have had advanced colorectal cancer, which has unfortunately spread to the lining of the abdomen. This type of cancer is difficult to treat and involves intricate surgery that lasts for around 8-10 hours. Patients after this surgery have kindly donated their tumours in order for our team to analyse them. We are looking at the DNA of the starting tumour and the DNA of the tumours that have spread, in order for us to see how closely related the two tumours are. This project has many elements to it and involves a large team, I’m working closely with surgeons, pathologists and lab researchers who are using state of the art techniques and facilities to get the most accurate results. My main role will be to analyse the raw results, which should start to become available within the next month. At the moment I am mainly delegating and in charge of organising, as there are many people involved, it can often be difficult, but I’m enjoying the communication aspect. Performing a DNA profile of the starting tumour (primary) is common practice in hospitals, as it helps doctors come up with a treatment plan tailored to the tumour type. A profile of the tumour that has spread (secondary) is not routinely done, therefore the profile of the primary is also used to treat the secondary. This project aims to see if there are any differences in DNA between the two, and whether the secondary site should also be analysed for establishing treatment plans. A lot of information can be gained by looking at the DNA of tumours, and more information is needed to help manage this advanced disease, which currently has a poor prognosis.

My project is a good mix of lab work and clinical; often projects are one or the other. This means I get the opportunity to explore both kinds of research. I am also exposed to many different environments, for example, I have sat down with pathologists and looked at tumour samples under the microscope, as well as having the opportunity to be in the genomics lab and understand the process of DNA profiling. Being able to have these experiences is one of the reasons why I took a year out of medicine. Despite having previous reservations about doing a Master’s (mainly due to adding an extra year to my already long 5 year degree!) I’m happy with the work I’m doing, and I have been enjoying experiencing the world of research.

Going Further…

1.  For more information on DNA and genes: https://www.genomicseducation.hee.nhs.uk/genetics101/what-is-dna/

2.  I am based at the world-renowned Christie Hospital which is pioneering in cancer research, for more information on the research they do have a look at their website: https://www.christie.nhs.uk/professionals/research/

3.  For general information about cancer, check out the Cancer Research UK website: https://www.cancerresearchuk.org/?gclid=EAIaIQobChMImcevrJDr3wIVCbDtCh2byAaqEAAYASAAEgII7vD_BwE&gclsrc=aw.ds#/

4.  For more information about applying for medicine at Manchester: https://www.manchester.ac.uk/study/undergraduate/courses/2019/01428/mbchb-medicine/

5.  For information about the Masters in oncology (cancer): https://www.manchester.ac.uk/study/masters/courses/list/08422/mres-oncology/